Today, many drugs are designed for sub-lingual administration, including cardiovascular drugs, steroids, barbiturates, enzymes and, increasingly, vitamins and minerals.
R2’s cannabidiol and cannabis derived formulations will be offered in a sub-lingual delivery system administered under the tongue. The diffusion of the cannabis formulation into the blood through the tissues under the tongue allows the quickest entrance into the bloodstream.
Our medical CBD / cannabis derivative/formulations for treating different medical conditions will be offered with replaceable cartridges allowing ease of use and accessibility for the patient selecting this method of delivery.
How does it work?
When a chemical comes in contact with the mucous membrane beneath the tongue, it diffuses through it. Because the connective tissue beneath the epithelium contains a profusion of capillaries, the substance then diffuses into them and enters the venous circulation. In contrast, substances absorbed in the intestines are subject to "first-pass metabolism" in the liver before entering the general circulation.
Sublingual administration has certain advantages over oral administration. Being more direct, it is often faster and it ensures that the substance will risk degradation only by salivary enzymes before entering the bloodstream, whereas orally administered drugs must survive passage through the hostile environment of the gastrointestinal tract,